Semaglutide Research Peptide — Buy GLP-1 Receptor Agonist (≥97% Purity)
Semaglutide (CAS 910463-68-2) is a fatty acid-conjugated GLP-1 (glucagon-like peptide-1) receptor agonist with 94% structural homology to endogenous human GLP-1. Developed as a long-acting GLP-1 analog, semaglutide has become one of the most important reference compounds in metabolic disease research, with a rapidly expanding body of preclinical and clinical literature. PureBond semaglutide is manufactured to ≥97% HPLC purity for rigorous in-vitro research applications.
Mechanism of Action
Semaglutide binds and activates the GLP-1 receptor (GLP-1R), a class B G-protein-coupled receptor expressed in pancreatic beta cells, the gastrointestinal tract, the cardiovascular system, and the central nervous system. Receptor activation stimulates glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and activates hypothalamic satiety centers. The C-18 fatty diacid linker of semaglutide enables albumin binding, extending its half-life and making it a preferred model compound for extended receptor studies.
Research Applications
- GLP-1 receptor signaling and pathway studies
- Glucose metabolism, insulin secretion, and beta-cell function research
- Appetite regulation and hypothalamic signaling models
- Cardiometabolic and cardiovascular protection studies
- Obesity, adipose tissue biology, and body composition research
Specifications
- Chemical Name: Semaglutide
- CAS Number: 910463-68-2
- Molecular Weight: 4,113.58 Da
- Purity: ≥97% (HPLC verified)
- Form: Lyophilized powder
- Available Sizes: 2mg, 5mg, 10mg
Storage & Handling
Store lyophilized semaglutide at −20°C, protected from light. Reconstitute with sterile or bacteriostatic water. Reconstituted solution should be stored at 4°C and used within 28 days. Minimize freeze-thaw cycles to preserve peptide integrity.
For in-vitro laboratory research use only. Not for human or animal consumption. Not a drug, supplement, or medicinal product.
